Ultrastructure of altered hepatocytes induced by diethylnitrosamine (DENA)

Dietary fructose enhances the incidence of precancerous hepatocytes induced by administration of diethylnitrosamine in rat

BACKGROUND Nonalcoholic fatty liver disease (NAFLD) is a risk for hepatocellular carcinoma (HCC), but the association between a high-fructose diet and HCC is not fully understood. In this study, we investigated whether a high-fructose diet affects hepatocarcinogenesis induced by administration of diethylnitrosamine (DEN). METHODS Seven-week-old male Sprague-Dawley rats were fed standard chow ...

Chemoprevention by Euphorbia Neriifolia of DENA-induced Mouse Renal Carcinogenesis

Kidney cancer is the third most common malignancy of the genitourinary system account for 2 to 3 % of all cancers in men worldwide, with 130,000 new cases and 63,000 deaths from the disease occurring annually (Ferlay et al., 2004). Certain toxic chemicals and medicines can cause renal damage, are recognized as a toxicological problem. NNitrosodiethylamine (DENA) is the most important environmen...

Transcription coactivator PBP/MED1-deficient hepatocytes are not susceptible to diethylnitrosamine-induced hepatocarcinogenesis in the mouse

Nuclear receptor coactivator [peroxisome proliferator-activated receptor-binding protein (PBP)/mediator subunit 1 (MED1)] is a critical component of the mediator transcription complex. Disruption of this gene in the mouse results in embryonic lethality. Using the PBP/MED1 liver conditional null (PBP/MED1(DeltaLiv)) mice, we reported that PBP/MED1 is essential for liver regeneration and the pero...

Metastatic rate of liver tumors induced by diethylnitrosamine in mice.

Primary neoplasms in dog liver induced by diethylnitrosamine.

Clinicopathological, angiographie, and histological stud ies were made on liver neoplasms in adult male mongrel dogs after administration of diethylnitrosamine. Primary hepatic neoplasms of various types developed in 14 male mongrel dogs upon administration of diethylnitrosamine for over 50 weeks. Grossly, the surface of the liver of these animals appeared finely granular, rubbery, and hard. Si...